Fascin
نویسندگان
چکیده
منابع مشابه
Arpless comets are fascin-ating
Lethargic mitochondria are left out he proper processing of a mitochondrial fusion protein called Mgm1 depends on sufficient ATP, based on results from Herlan et al. (page 167). Mgm1's energy dependence may ensure that tired mitochondria get left behind. Mgm1 can be found in the mitochondrial intermembrane space in two forms, the shorter of which (s-Mgm1) is generated by protease cleavage of th...
متن کاملFascin expression in colorectal carcinomas
PURPOSE The purpose of this study was to investigate the significance of fascin expression in colorectal carcinoma. METHODS This is a retrospective study of 167 consecutive, well-documented cases of primary colorectal adenocarcinoma for which archival material of surgical specimens from primary tumor resections were available. We chose a representative tissue sample block and examined fascin ...
متن کاملCell-matrix adhesions differentially regulate fascin phosphorylation.
Cell adhesion to individual macromolecules of the extracellular matrix has dramatic effects on the subcellular localization of the actin-bundling protein fascin and on the ability of cells to form stable fascin microspikes. The actin-binding activity of fascin is down-regulated by phosphorylation, and we used two differentiated cell types, C2C12 skeletal myoblasts and LLC-PK1 kidney epithelial ...
متن کاملRole of fascin in filopodial protrusion
In this study, the mechanisms of actin-bundling in filopodia were examined. Analysis of cellular localization of known actin cross-linking proteins in mouse melanoma B16F1 cells revealed that fascin was specifically localized along the entire length of all filopodia, whereas other actin cross-linkers were not. RNA interference of fascin reduced the number of filopodia, and remaining filopodia h...
متن کاملMechanism of actin filament bundling by fascin.
Fascin is the main actin filament bundling protein in filopodia. Because of the important role filopodia play in cell migration, fascin is emerging as a major target for cancer drug discovery. However, an understanding of the mechanism of bundle formation by fascin is critically lacking. Fascin consists of four β-trefoil domains. Here, we show that fascin contains two major actin-binding sites,...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2010
ISSN: 1942-0889
DOI: 10.4161/cib.3.3.11556